The church was formed in 1722 or 1723, based on a recommendation by members of The East Precinct Church of Yarmouth to build a second location closer to where most members lived.

Rev. Josiah Dennis, a young graduate of Harvard College in 1725, was called to serve the new parish, assuming his position in 1727. He served 36 years, until his death in 1763.

Rev. Nathan Stone was called to succeed Rev. Josiah Dennis and served 40 years, from 1764 until his death in 1804.